Tumor Growth, Invasion and Metastasis

 

SDSU Co-Leader

Mike Bergdahl, Ph.D.

UCSD Co-Leader

Judith A. Varner, Ph.D.

 

ABSTRACT

Azaspirene is a potential new treatment for cancer and inflammation.  Azaspirene may serve as an inexpensive anti-cancer drug for populations exposed to higher risks for cancer, including ethnic minorities who exhibit breast cancer prognoses with associated inflammation.  We plan to complete the preparation of azaspirene and new molecular analogs of this drug at SDSU and to test its potency in models of cancer and inflammation at UCSD.  During this endeavor, we will train under-represented students and postdoctoral fellows at both institutions to perform cancer-related research.  We will also submit future grant applications to NCI/NIH as a consequence of the preliminary results obtained from this study.

Project Period: 9/1/2011 – 8/31/2012

Selected Outcomes

Publications

Dibrov, S. M.; Ding, K.; Brunn, N.; Parker, M.; Bergdahl, M. B.; Wyles, D. L.; Hermann, T.  Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches.  Proceedings of the National Academy of Sciences, 2012,109 (14), 5223-5228.

Burley, S. B.; Lam, V. V.; Lakner, F. J.; Mikael Bergdahl, M., B.; Parker, M.A. A Diversity-Optimized Route to the Ergoline Skeleton via Intramolecular Heck Cyclization of 4-Unsubstituted Indoles. Org. Lett 2013 In Press.

Dibrov, S. M.; Parker, M.; Bergdahl, M. B.; Hermann, T Crystal structure of a benzimidazole hepatitis C virus inhibitor free and in complex with the viral RNA target.. Journal of Chemical Crystallography, In Press 2013.

Grant Proposals

1 application to NIH pending

1 application to San Diego Foundation pending

Presentations

Schmit, D.; Barker, M. Azaspirene, Poster: A Novel Angiogenesis Inhibitor.  2013 Research Reception, American Cancer Society Cancer Action Network, AMN Healthcare, San Diego, CA, April 4, 2013.

Schmit, D.; Burley, S.; Kivlahan, K.; Siracusa, A.; Parker, M.; Bergdahl, M. Crystal Structure Based Library of new Small Molecules Active against the Hepatitis C Virus HCV. 25th Annual CSU Biotechnology Symposium, Anaheim Marriott, Anaheim, January 3-4, 2013, Abstract 239.

Rodriguez, J.; Montgomery, T.; Bergdahl, M. Copper catalyzed conjugate additions of vinyl groups using alkenyl boronic acids and alkenyl boronic esters. 2012 Summer Research Conference, University of California, San Diego, August 16, 2012.

Rodriguez, J.; Montgomery, T.; Bergdahl, M. Copper catalyzed conjugate additions of vinyl groups using alkenyl boronic acids and alkenyl boronic esters. Ronald E. McNair Scholars Program 20th California Scholars Program Symposium, University of California, Berkeley, August 2-5, 2012.

Nevchas-Lerario, I.; Bergdahl, M.; Carrano, C. H.; Separovic, F.; Metzger, R.P. Conformation of the Diacetate of Virginiamycin M1 (Pristinamycin IIA, Streptogramin A), 243rd National Meeting, American Chemical Society, San Diego, California, 2012, March 25-29, MEDI 386.

Schmit, D.; Barker, M.; Montgomery, T.; Rovira, A.; Bergdahl, M. Diversity oriented total synthesis of analogs derived from azaspirene: Powerful inhibitor of angiogenesis and inflammation. 243′rd National American Chemical Society Meeting, San Diego, California, March 25-29, 2012, ORGN 248.

Parker, M.; Burley, S.; Colla, A.; Eccker, D.; Croux, C.; Lakner, F.; Lam, V.; Bergdahl. M Ergot alkaloid analogs: Engineering a library-optimized route. 243’rd National American Chemical Society Meeting, San Diego, California, March 25-29, 2012, ORGN 788.

Banasik, B.; Wang, L.; Bergdahl, M. Synthesis of lagunamides: Antimalarial and cytotoxic natural products from the marine cyanobacterium lyngbya majuscule. 243’rd National American Chemical Society Meeting, San Diego, California, March 25-29, 2012, ORGN 247.

Burley, S.; Eccker, D.; Colla, A.; Parker, M.; Bergdahl, An Optimized Synthesis of New Biologically Active Ergot Derivatives. 24th Annual CSU Biotechnology Symposium, Santa Clara Marriott, Santa Clara, January 6-7, 2012, Abstract 50.

Kivlahan, K.; Mendez, Y.; Parker, M.; Bergdahl, M. Crystal Structure of the HCV RNA Binding to a Small Molecule – Synthesis and Diversity of New HCV Drugs. 24th Annual CSU Biotechnology Symposium, Santa Clara Marriott, Santa Clara, January 6-7, 2012, Abstract 52.

Banasik, B.; Wang, L.; Bergdahl, M. Synthesis of Lagunamides: Antimalarial and Cytotoxic Natural Products from the Marine Cyanobacterium Lyngbya majascula. 24th Annual CSU Biotechnology Symposium, Santa Clara Marriott, Santa Clara, January 6-7, 2012, Abstract 226.

Schmit, D.; Barker, M.; Montgomery, T.; Mendez, Y.; Bergdahl, M. Diversity Oriented Total Synthesis of Pseurotin Analogs – Powerful Inhibitor of Angiogenesis and Inflammation. 24th Annual CSU Biotechnology Symposium, Santa Clara Marriott, Santa Clara, January 6-7, 2012, Abstract 228.