Sphingadienes for the Prevention of Breast Cancer Tumorigenesis


SDSU Co-Leader

Greg Harris Ph.D.

UCSD Co-Leader

Jing Yang, Ph.D.



Soy is enriched in naturally occurring dietary components called sphingadienes. Sphingadienes have recently been shown to inhibit growth of intestinal cancers in the laboratory. Our hypothesis is that sphingadienes may play a beneficial role in breast cancer prevention and treatment.  The aims of this proposal are to isolate the sphingadienes (SDS) and assess whether they inhibit the growth of human breast cancer cells in the laboratory (at SDSU and UCSD) and in mice that have human breast cancer cell tumors (at UCSD).  Understanding how dietary agents affect the incidence and outcome of breast cancer treatment will be important in addressing health disparities among the medically underserved.

Project Period: 9/1/2010 – 8/31/2012