Anti-tumor Effects of D-Amino Acid Peptides that Stabilize DNA Repair Intermediate

 

SDSU Co-Leader

Anca Segall, Ph.D.

UCSD Co-Leader

William Wachsman, M.D., Ph.D.

 

ABSTRACT

Tumor cells replicate and divide more frequently than normal cells.  As a consequence, they tend to accumulate more replication errors.  Many chemotherapeutic treatments take advantage of this attribute by inhibiting DNA replication and/or events of the cell cycle.  DNA repair appears to be a fairly common mechanism by which tumor cells can reverse and escape the effects of chemotherapeutics.  We will investigate the effects on prostate cancer cells of a new class of inhibitors whose target appears to be DNA repair, when used on their own or in combination with other drugs commonly used to treat prostate cancer.

Project Period: 9/1/2010 – 8/31/2012